In the world of Oppai Heart, a mysterious medicine transforms the lives of students at a high school. When Ryuya and his friends accidentally consume the potion, they become sexually sensitive and irresistibly attracted to one another. As the girls' breasts grow larger, they need to engage in intimate acts to regain control of their desires. Ryuya takes on the role of savior, satisfying the needs of his female classmates and aiding in the creation of a vaccine. As the school becomes a hotbed of passion, one thing is certain: everyone is in desperate need of more.

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